2004年-2008年 武汉大学生命科学学院生物学基地班 学士
2008年-2014年 武汉大学生命科学学院发育生物学 博士
2015年-2021年 University of California, Riverside. Department of Chemistry 博士后
2021年- beat365 长聘教轨副教授、博士生导师

课题组招收博士和硕士研究生，热忱欢迎准备攻读硕士、博士学位的青年才俊加入！诚聘博士后青年人才！

本课题组精通化学生物学、细胞生物学、分子生物学、生物信息学、蛋白组学、多组学分析、高通量测序分析等技术，致力于发展蛋白组学研究新方法，推动包括基因组学、转录组学、蛋白组学和代谢组学等多组学整合分析策略在疾病诊断及治疗中的应用，注重多学科交叉前沿研究领域。
主要研究方向为：
1. G-四联体结合蛋白的鉴定以及其在疾病发生中的功能作用机制研究；
2. 基于高通量高精准度定量靶向蛋白组学技术进行疾病中表观遗传学的研究。
3. 基于多组学整合分析技术进行肿瘤早期诊断和靶向治疗研究


课题组长期招聘硕士/博士研究生、博士后青年人才！期待您的加入！
联系邮箱 linli.sjtu@sjtu.edu.cn

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2. Mondal S, Ramanathan M, Miao W, Meyers RM, Rao D, Lopez-Pajares V, Siprashvili Z, Reynolds DL, Porter DF, Ferguson I, Neela P, Zhao Y, Meservey LM, Guo M, Yang YY, Li L, Wang Y, Khavari PA. PROBER identifies proteins associated with programmable sequence-specific DNA in living cells. Nat Methods. 2022 Aug;19(8):959-968. doi: 10.1038/s41592-022-01552-w. Epub 2022 Aug 4.

3. Chen JJ, You XJ, Li L, Xie NB, Ding JH, Yuan BF, Feng YQ. Single-Base Resolution Detection of Adenosine-to-Inosine RNA Editing by Endonuclease-Mediated Sequencing. Anal Chem. 2022 Jun 21;94(24):8740-8747. doi: 10.1021/acs.analchem.2c01226. Epub 2022 Jun 9.

4. Guo S, Li L, Yu K, Tan Y, Wang Y. LC-MS/MS for Assessing the Incorporation and Repair of N(2)-Alkyl-2'-deoxyguanosine in Genomic DNA. Chem Res Toxicol. 2022 Oct 17;35(10):1814-1820. doi: 10.1021/acs.chemrestox.2c00101. Epub 2022 May 18.

5. Ma CJ, Li L, Shao WX, Ding JH, Cai XL, Lun ZR, Yuan BF, Feng YQ. An enzyme-mediated bioorthogonal labeling method for genome-wide mapping of 5-hydroxymethyluracil. Chem Sci. 2021 Oct 4;12(42):14126-14132. doi: 10.1039/d1sc03812e. eCollection 2021 Nov 3.

6. Gao Z, Williams P, Li L, Wang Y. A Quantitative Proteomic Approach for the Identification of DNA Guanine Quadruplex-Binding Proteins. J Proteome Res. 2021 Nov 5;20(11):4919-4924. doi: 10.1021/acs.jproteome.1c00603. Epub 2021 Sep 27.

7. Tan Y, Guo S, Wu J, Du H, Li L, You C, Wang Y. DNA Polymerase η Promotes the Transcriptional Bypass of N(2)-Alkyl-2'-deoxyguanosine Adducts in Human Cells. J Am Chem Soc. 2021 Oct 6;143(39):16197-16205. doi: 10.1021/jacs.1c07374. Epub 2021 Sep 23.

8. Liu X, Yuan J, Zhang X, Li L, Dai X, Chen Q, Wang Y. ATF3 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an N(6)-Methyladenosine-Based Epitranscriptomic Mechanism. Chem Res Toxicol. 2021 Jul 19;34(7):1814-1821. doi: 10.1021/acs.chemrestox.1c00206. Epub 2021 Jul 2.

9. Bade D, Cai Q, Li L, Yu K, Dai X, Miao W, Wang Y. Modulation of N-terminal methyltransferase 1 by an N(6)-methyladenosine-based epitranscriptomic mechanism. Biochem Biophys Res Commun. 2021 Mar 26;546:54-58. doi: 10.1016/j.bbrc.2021.01.088. Epub 2021 Feb 6.

10. Li L, Williams P, Gao Z, Wang Y. VEZF1-guanine quadruplex DNA interaction regulates alternative polyadenylation and detyrosinase activity of VASH1. Nucleic Acids Res. 2020 Dec 2;48(21):11994-12003. doi: 10.1093/nar/gkaa1092.

11. Li L, Williams P, Ren W, Wang MY, Gao Z, Miao W, Huang M, Song J, Wang Y. YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression. Nat Chem Biol. 2021 Feb;17(2):161-168. doi: 10.1038/s41589-020-00695-1. Epub 2020 Nov 16.

12. Liu X, Gonzalez G, Dai X, Miao W, Yuan J, Huang M, Bade D, Li L, Sun Y, Wang Y. Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m(6)A-Based Epitranscriptomic Mechanism. Mol Ther. 2020 Dec 2;28(12):2593-2604. doi: 10.1016/j.ymthe.2020.09.007. Epub 2020 Sep 5.

13. Yang YY, Yu K, Li L, Huang M, Wang Y. Proteome-wide Interrogation of Small GTPases Regulated by N(6)-Methyladenosine Modulators. Anal Chem. 2020 Jul 21;92(14):10145-10152. doi: 10.1021/acs.analchem.0c02203. Epub 2020 Jul 7.

14. Qi TF, Guo L, Huang M, Li L, Miao W, Wang Y. Discovery of TBC1D7 as a Potential Driver for Melanoma Cell Invasion. Proteomics. 2020 Jul;20(14):e1900347. doi: 10.1002/pmic.201900347. Epub 2020 Jul 2.

15. Miao W, Li L, Liu X, Qi TF, Guo L, Huang M, Wang Y. A Targeted Quantitative Proteomic Method Revealed a Substantial Reprogramming of Kinome during Melanoma Metastasis. Sci Rep. 2020 Feb 12;10(1):2485. doi: 10.1038/s41598-020-59572-5.

16. Dai X, Gonzalez G, Li L, Li J, You C, Miao W, Hu J, Fu L, Zhao Y, Li R, Li L, Chen X, Xu Y, Gu W, Wang Y. YTHDF2 Binds to 5-Methylcytosine in RNA and Modulates the Maturation of Ribosomal RNA. Anal Chem. 2020 Jan 7;92(1):1346-1354. doi: 10.1021/acs.analchem.9b04505. Epub 2019 Dec 23.

17. Liu X, Miao W, Huang M, Li L, Dai X, Wang Y. Elevated Hexokinase II Expression Confers Acquired Resistance to 4-Hydroxytamoxifen in Breast Cancer Cells. Mol Cell Proteomics. 2019 Nov;18(11):2273-2284. doi: 10.1074/mcp.RA119.001576. Epub 2019 Sep 13.

18. Miao W, Li L, Wang Y. High-Throughput Targeted Quantitative Analysis of the Interaction between HSP90 and Kinases. Anal Chem. 2019 Sep 17;91(18):11507-11509. doi: 10.1021/acs.analchem.9b03320. Epub 2019 Sep 4.

19. Miao W, Li L, Zhao Y, Dai X, Chen X, Wang Y. HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N(6)-methyladenosine. Nat Commun. 2019 Aug 9;10(1):3613. doi: 10.1038/s41467-019-11552-8.

20. Wu J, Du H, Li L, Price NE, Liu X, Wang Y. The Impact of Minor-Groove N(2)-Alkyl-2'-deoxyguanosine Lesions on DNA Replication in Human Cells. ACS Chem Biol. 2019 Aug 16;14(8):1708-1716. doi: 10.1021/acschembio.9b00129. Epub 2019 Aug 1.

21. Li L, Miao W, Williams P, Guo C, Wang Y. SLIRP Interacts with Helicases to Facilitate 2'-O-Methylation of rRNA and to Promote Translation. J Am Chem Soc. 2019 Jul 17;141(28):10958-10961. doi: 10.1021/jacs.9b04424. Epub 2019 Jul 3.

22. Miao W, Yuan J, Li L, Wang Y. Parallel-Reaction-Monitoring-Based Proteome-Wide Profiling of Differential Kinase Protein Expression during Prostate Cancer Metastasis in Vitro. Anal Chem. 2019 Aug 6;91(15):9893-9900. doi: 10.1021/acs.analchem.9b01561. Epub 2019 Jul 10.

23. Du H, Wang P, Li L, Wang Y. Repair and translesion synthesis of O(6)-alkylguanine DNA lesions in human cells. J Biol Chem. 2019 Jul 19;294(29):11144-11153. doi: 10.1074/jbc.RA119.009054. Epub 2019 Jun 5.

24. Tang F, Liu S, Li QY, Yuan J, Li L, Wang Y, Yuan BF, Feng YQ. Location analysis of 8-oxo-7,8-dihydroguanine in DNA by polymerase-mediated differential coding. Chem Sci. 2019 Mar 11;10(15):4272-4281. doi: 10.1039/c8sc04946g. eCollection 2019 Apr 21.

25. Su Y, Ghodke PP, Egli M, Li L, Wang Y, Guengerich FP. Human DNA polymerase η has reverse transcriptase activity in cellular environments. J Biol Chem. 2019 Apr 12;294(15):6073-6081. doi: 10.1074/jbc.RA119.007925. Epub 2019 Mar 6.

26. Du H, Wang P, Li L, Amato NJ, Wang Y. Cytotoxic and Mutagenic Properties of C1' and C3'-Epimeric Lesions of 2'-Deoxyribonucleosides in Human Cells. ACS Chem Biol. 2019 Mar 15;14(3):478-485. doi: 10.1021/acschembio.8b01126. Epub 2019 Feb 25.

27. Li L, Miao W, Huang M, Williams P, Wang Y. Integrated Genomic and Proteomic Analyses Reveal Novel Mechanisms of the Methyltransferase SETD2 in Renal Cell Carcinoma Development. Mol Cell Proteomics. 2019 Mar;18(3):437-447. doi: 10.1074/mcp.RA118.000957. Epub 2018 Nov 28.

28. Chen X, Li L, Xu B, Zhao S, Lu P, He Y, Ye T, Feng YQ, Wu Y. Phosphatidylinositol-specific phospholipase C2 functions in auxin-modulated root development. Plant Cell Environ. 2019 May;42(5):1441-1457. doi: 10.1111/pce.13492. Epub 2018 Dec 11.

29. Miao W, Li L, Wang Y. Identification of Helicase Proteins as Clients for HSP90. Anal Chem. 2018 Oct 16;90(20):11751-11755. doi: 10.1021/acs.analchem.8b03142. Epub 2018 Sep 26.

30. Huang M, Qi TF, Li L, Zhang G, Wang Y. A Targeted Quantitative Proteomic Approach Assesses the Reprogramming of Small GTPases during Melanoma Metastasis. Cancer Res. 2018 Sep 15;78(18):5431-5445. doi: 10.1158/0008-5472.CAN-17-3811. Epub 2018 Aug 2.

31. Du H, Leng J, Wang P, Li L, Wang Y. Impact of tobacco-specific nitrosamine-derived DNA adducts on the efficiency and fidelity of DNA replication in human cells. J Biol Chem. 2018 Jul 13;293(28):11100-11108. doi: 10.1074/jbc.RA118.003477. Epub 2018 May 22.

32. Miao W, Li L, Wang Y. A Targeted Proteomic Approach for Heat Shock Proteins Reveals DNAJB4 as a Suppressor for Melanoma Metastasis. Anal Chem. 2018 Jun 5;90(11):6835-6842. doi: 10.1021/acs.analchem.8b00986. Epub 2018 May 11.

33. Wu J, Wang P, Li L, You C, Wang Y. Cytotoxic and mutagenic properties of minor-groove O(2)-alkylthymidine lesions in human cells. J Biol Chem. 2018 Jun 1;293(22):8638-8644. doi: 10.1074/jbc.RA118.003133. Epub 2018 Apr 23.

34. Williams P, Li L, Dong X, Wang Y. Identification of SLIRP as a G Quadruplex-Binding Protein. J Am Chem Soc. 2017 Sep 13;139(36):12426-12429. doi: 10.1021/jacs.7b07563. Epub 2017 Sep 5.

35. Tam LM, Jiang J, Wang P, Li L, Miao W, Dong X, Wang Y. Arsenite Binds to the Zinc Finger Motif of TIP60 Histone Acetyltransferase and Induces Its Degradation via the 26S Proteasome. Chem Res Toxicol. 2017 Sep 18;30(9):1685-1693. doi: 10.1021/acs.chemrestox.7b00146. Epub 2017 Sep 7.

36. Liu Y, Perez L, Gill AD, Mettry M, Li L, Wang Y, Hooley RJ, Zhong W. Site-Selective Sensing of Histone Methylation Enzyme Activity via an Arrayed Supramolecular Tandem Assay. J Am Chem Soc. 2017 Aug 16;139(32):10964-10967. doi: 10.1021/jacs.7b05002. Epub 2017 Aug 8.

37. Li L, Wang Y. Cross-talk between the H3K36me3 and H4K16ac histone epigenetic marks in DNA double-strand break repair. J Biol Chem. 2017 Jul 14;292(28):11951-11959. doi: 10.1074/jbc.M117.788224. Epub 2017 May 25.

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李林博士，本科毕业于武汉大学，并于2015年获得武汉大学博士学位。博士毕业后在University of California，Riverside化学系从事科研工作。2021年加入beat365，任长聘教轨副教授、课题组组长、博士生导师，入选上海市海外高层次引进人才计划与国家海外高层次人才计划（青年）。目前主要研究方向为化学生物学、分子生物学、蛋白组学、多组学分析等。近年来在Nat Chem Biol., J Am Chem Soc., Nat Com., Nucleic Acids Res., Chem Sci., Cell Rep., Anal Chem.等著名期刊发表三十多篇论文。