Director:
Wei Jia, Ph.D. Radiopharmaceutical Chemistry (University of Missouri – Columbia, Missouri, U. S. A), Professor and Group Leader
Members
Aihua Zhao, Ph.D. Natural Product Chemistry (Kunming Institute of Botany, Chinese Academy of Sciences)
Yinan Zhang, Ph.D. Bioinformatics (University of Sydney, Australia)
Jiajian Liu, BS Preventive Medicine in Health Quarantine( GuangDong Pharmaceutical College)
Research Field
On-going Researches:
Develop Metabolomic methodologies and applications
TCM especially natural herbal drugs investigation
Publications & Patents
(1)Qiu, Y.; Cai, G.; Su, M.; Chen, T.; Zheng, X.; Xu, Y.; Ni, Y.; Zhao, A.; Xu, L. X.; Cai, S.; Jia, W., Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS. Journal of Proteome Research (IF=5.684, 2008), 2009, 8, (10), 4844-50.
(2)Xie, G.; Zheng, X.; Qi, X.; Cao, Y.; Chi, Y.; Su, M.; Ni, Y.; Qiu, Y.; Liu, Y.; Li, H.; Zhao, A.; Jia, W., Metabonomic Evaluation of Melamine-Induced Acute Renal Toxicity in Rats. Journal of Proteome Research (IF=5.684, 2008), 2009.
(3)Wang, Xiaoyan; Zhao, Tie; Qiu, Yunping; Su, Mingming; Jiang, Tao; Zhou, Mingmei; Zhao, Aihua; Jia, Wei. A Metabonomics Approach to Understanding Acute and Chronic Stress in Rat Models. Journal of Proteome Research (IF=5.684, 2008),2009, 8, (5), 2511-2518.
(4)Xiangping Chu, Tie Zhao, Yuanyuan Zhang, Aihua Zhao, Mingmei Zhou, Xiaojiao Zheng,Mo Dan1, Wei Jia. Determination of 13 Free Fatty Acids in Pheretima Using Ultra-Performance LC-ESI-MS. Chromatographia (IF=1.312, 2008),2009, 69, 645-652.
(5)Zhao, Tie; Chen, Tianlu; Qiu, Yunping; Zou, Xiangyu; Li, Xin; Yan, Chonghai; Su, Mingming; Zhao, Aihua; Jia, Wei. Trace Element Profiling using Inductively Coupled Plasma Mass Spectrometry and its Application in an Osteoarthritis Study. Analytical Chemistry (IF=5.712, 2008), 2009 May 1;81(9):3683-92.
(6)Xie, Guoxiang; Ye, Mao; Wang, Yungang; Ni, Yan; Su, Mingming; Huang, Hua; Qiu, Mingfeng; Zhao, Aihua; Zheng, Xiaojiao; Chen, Tianlu; Jia, Wei. Characterization of Pu-erh Tea Using Chemical and Metabolic Profiling Approaches. Journal of Agricultural and Food Chemistry (IF=2.562, 2008). 2009, 57 (8), pp 3046–3054.
(7)Dan, M.; Xie, G.; Gao, X.; Long, X.; Su, M.; Zhao, A.; Zhao, T.; Zhou, M.; Qiu, Y.; Jia, W., A rapid ultra-performance liquid chromatography-electrospray Ionisation mass spectrometric method for the analysis of saponins in the adventitious roots of Panax notoginseng. Phytochemical Analysis (IF=1.542, 2008), 2009, 20, (1), 68-76.
(8)Yuqian Bao, Tie Zhao, Xiaoyan Wang, Yunping Qiu, Mingming Su, Weiping Jia, Wei Jia. Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers. Journal of Proteome Research (IF=5.684, 2008), 2009, 8 (4), 1623-1630
(9)Houkai Li, Mingmei Zhou, Aihua Zhao, Wei Jia. Traditional Chinese Medicine: Balancing the Gut Ecosystem. Phytotherapy Reasearch, 2009, 23 (9) , 1332-1335.
(10)Houkai Li, Zuoquan Xie, Jingchao Lin, Huaiguang Song, Qi Wang, Ke Wang, Mingming Su, Yunping Qiu, Tie Zhao, Kai Song, Xiaoyan Wang, Mingmei Zhou, Ping Liu, Guoping Zhao, Qinghua Zhang, Wei Jia. Transcriptomic and Metabonomic Profiling of Obesity-Prone and Obesity-Resistant Rats under High Fat Diet. Journal of Proteome Research (IF=5.684, 2008), 2008, 7，4775－4783.
(11)Dan, M.; Su, M.; Gao, X.; Zhao, T.; Zhao, A.; Xie, G.; Qiu, Y.; Zhou, M.; Liu, Z.; Jia, W., Metabolite profiling of Panax notoginseng using UPLC-ESI-MS. Phytochemistry (IF=2.322) , 2008, 69, (11), 2237-2244.
(12)Jingchao Lin, Mingming Su, Xiaoyan Wang, Yunping Qiu, Houkai Li, Jin Hao, Hongzhou Yang, Mingmei Zhou, Chao Yan, Wei Jia. Multiparametric analysis of amino acids and organic acids in rat brain tissues using GC/MS. Journal of Separation Science (IF=2.632), 2008, 31: 2831-2838.
(13)Yan Ni, Mingming Su, Jingchao Lin, Xiaoyan Wang, Yunping Qiu, Aihua Zhao, Tianlu Chen, Wei Jia. Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress. FEBS Letters (IF=3.263) , 2008, 582(17): 2627-2636.
(14)Xiumei Tao, Yumin Liu, Yihuang Wang, Yunping Qiu, Jingchao Lin, Aihua Zhao, Mingming Su and Wei Jia. GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia. Analytical and Bioanalytical Chemistry (IF=2.867), 2008, 2881-2889.
(15)Qing Shen, Xin Li, Yunping Qiu, Mingming Su, Yumin Liu, Houkai Li, Xiaoyan Wang, Xiangyu Zou, Chonghuai Yan, Lan Yu, Sheng Li, Chunling Wan, Lin He, and Wei Jia. Metabonomic and Metallomic Profiling in the Amniotic Fluid of Malnourished Pregnant Rats. Journal of Proteome Research (IF=5.675), 2008, 7(5), 2151–2157.
(16)Guoxiang Xie, Plumb R., Mingming Su, Zhaohui Xu,Aihua Zhao, Mingfeng Qiu,Xiangbao Long, Zhong Liu, Wei Jia, Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research. Journal of Separation Science (IF=2.632), 2008 Apr;31(6-7):1015-26.
(17)Guo X. Xie, Yan Ni, Ming M. Su, Yuan Y. Zhang, Ai H. Zhao, Xian F. Gao, Zhong Liu ,Pei G. Xiao, Wei Jia. Application of ultra-performance LC-TOF MS metabolite profiling techniques to the analysis of medicinal Panax herbs. Metabolomics, 2008, 4:248–260.
(18)Xian-Fu Gao, Mo Dan, Ai-Hua Zhao, Wei Jia. Simultaneous analysis of nine saponins in flower buds of Panax notoginseng using high performance liquid chromatography [J]. Biomedical Chromatography (IF=1.663), 2008 Mar;22(3):244-9.
(19)Wei Jia, Houkai Li, Liping Zhao, Jeremy.K.Nicholson. Gut microbiota: a potential new territory for drug targeting, Nature Reviews Drug Discovery (IF=23.308), 7,123-129, 2008.
(20)Zhaohui Xu, Xiaoyan Wang, Jianwen Liu, Wei Jia. The anti-diabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats, Phytotherapy Research (IF = 1.143), 22, 97-101, 2008.
(21)Chen, Minjun; Ni, Yan; Duan, Hongquan; Qiu, Yunping; Guo, Congying; Jiao, Yang; Shi, Huijuan; Su, Mingming，Wei Jia, Mass Spectrometry-based Metabolic Profiling of Rat Urine Associated with General Toxicity Induced by Multiglycoside of Tripterygium Wilfordii Hook. F. Chemical Research in Toxicology (IF=3.508), 2007, 288-294
(22)Xie GX, Su MM, Li P, Gu X, Yan C, Qiu YP, Li HK, Jia W. Analysis of urinary metabolites for metabolomic study by pressurized capillary electrochromatography [J]. Electrophoresis. (IF =3.609), 28, 4459-4468, 2007.
(23)Xiaoyan Wang, Tie Zhao, Xianfu Gao, Mo Dan, Mingmei Zhou, Wei Jia, Simultaneous Determination of 17 Ginsenosides in Rat Urine by Ultra Performance Liquid Chromatography-mass Spectrometry with Solid-phase Extraction, Analytica Chimica Acta (IF = 3.186), 594, 265-273, 2007.
(24)Xiaoyan Wang, Mingming Su, Yunping Qiu, Yan Ni, Tie Zhao, Mingmei Zhou, Aihua Zhao, Shengli Yang, Wei Jia, Metabolic Regulatory Network Alterations in Response to Acute Cold Stress and Ginsenoside Intervention, Journal of Proteome Research (IF = 5.675), Vol. 6 (9) 3449-3455, 2007.
(25)Houkai Li, Yan Ni, Mingming Su, Yunping Qiu, Mingmei Zhou, Mingfeng Qiu, Aihua Zhao, Liping Zhao, Wei Jia, Pharmaco-metabonomic phenotying reveals different responses to xenobiotic intervention in rats, Journal of Proteome Research (IF=5.675), Vol. 6 (4) 1364-1370, 2007.
(26)Minjun Chen, Mingming Su, Liping Zhao, Jiye Cheng, Yijiang La, Yumin Liu, Wei Jia, Metabonomic Study of Aristolochic Acid Induced Nephrotoxicity in Rats, Journal of Proteome Research (IF=5.675), Vol. 5 (4), 995-1002, 2006.
(27)Minjun Chen, Liping Zhao, Wei Jia, Metabonomic study on the biochemical profiles of a hydrocortisone induced animal model, Journal of Proteome Research (IF=5.675), Vol. 4 (6) 2391-2396, 2005.
(28)Yan Ni, Mingming Su, Yunping Qiu, Minjun Chen, Yumin Liu, Wei Jia, Metabolic profiling using combined GC-MS and LC-MS provides a systems understanding of aristolochic acid-induced nephrotoxicity in rat, FEBS Letters (IF=3.263), Vol. 581, Issue 4, 2007.
(29)Yunping Qiu, Mingming Su, Yumin Liu, Minjun Chen, Jingjing Gu, Ji Zhang, and Wei Jia, Application of ethyl chloroformate derivatization for gas chromatography-mass spectrometry based metabonomic profiling, Analytica Chimica Acta (IF = 3.186), 583, 277-283, 2007.
(30)Guoxiang Xie, Aihua Zhao, Peng Li, Lu Li, Wei Jia. Fingerprint analysis of Rhizoma chuanxiong by pressurized capillary electrochromatography and high performance liquid chromatography. Biomedical chromatography (IF = 1.663). 21(8): 867–875, 2007.
(31)Xiangping Chu, Zhaohui Xu, Dazheng Wu, Aihua Zhao, Mingmei Zhou, Mingfeng Qiu, Wei Jia. In vitro and in vivo evaluation of the anti-asthmatic activities of fractions from Pheretima. Journal of Ethnopharmacology (IF = 2.049), 111, 490-495, 2007.
(32)Yang Jiao, Mingming Su, Minjun Chen, Wei Jia, Yiqun Chou, Zhongyi Huang, Nanlin Yang, Weida Tong. LC/ESI-MS method for the determination of trimetazidine in human plasma: Application to a bioequivalence study on Chinese volunteers. Journal of pharmaceutical and biomedical analysis (IF = 2.761), 43 (5): 1804-1807 APR 11 2007.
(33)Guoxiang Xie, Yunping Qiu, Mingfeng Qiu, Xianfu Gao, Wei Jia, Analysis of dencichine in Panax notoginseng by gas chromatography-mass spectrometry with ethyl chloroformate derivatization, Journal of Pharmaceutical and Biomedical Analysis (IF = 2.761), Vol 43/3 920-925, 2007.
contact information
School of Pharmacy, Shanghai Jiao Tong University
800 Dongchuan Road, Shanghai, 200240
Office phone: +86-21-3420-4829
Lab. Phone: +86-21-3420-4816
Fax: +86-21-3420-4829
