Laboratory of Microbial Pharmaceuticals
Director:
Daijie Chen Ph.D. Microbial Biochemical Pharmaceuticals (Shanghai Institute of Pharmaceutical Industry.), Professor and doctoral tutor, vice dean of pharmacy school
Education:
1978-1982 East China University of Technology, Shanghai, China B.S Biotechnology
1983-1986 Shanghai Institute of Pharmaceutical Industry, Shanghai, China M.S Microbial and biochemical pharmaceuticals
1986-1989 Shanghai Institute of Pharmaceutical Industry, Shanghai, China Ph.D Microbial and biochemical pharmaceuticals
1999-1990 Institute of Microbial Chemistry in Japan, Postdoc fellow, worked on screening of bioactive substance from microorganisms.
Members
Xiuping Qian, PhD, Associate Professor
Mei Ge, PhD, Associate Researcher
Wenwei Mao, PhD, Associate Professor
Minyu Luo, M. S, Associate Researcher
Yu Yin, PhD, Research Researcher
Li Zhu, PhD, Research Assistant
Tian Yang, B.S. Technician
Wenxiang Jin, B.S. Technician
Publications & Patents
Principal Research Interests:
[1] Discovery of novel and high active hybrid antibiotics based on the reconstruction of the pathways for known antibiotics biosynthesis
[2] Screening new bioactive substances from microbial metabolites
[3] Discovery of new bioactive substances based on the mining of biosynthetic elements
Other Professional Activities:
[1] Reviewer for Process Biochemistry, Chemistry Process, Current Microbiology, Bioresource Technology, Journal of Chromatography A, and Biochemical Bioengineering
[2] Member of both Chinese Pharmacopoeia Commission and Chinese Pharmacopoeia Commission for Animals
[3] Vice Director of Chinese Board of Antibiotic Specialties of Chinese Pharmaceutical Association
[4] Vice President of Shanghai Society for Genetics
[5] Director of Shanghai Board of Antibiotic Specialties of Shanghai Pharmaceutical Association
[6] Member of Editing Committee for Chinese Journal of Antibiotics, Chinese Journal of Pharmaceuticals and Journal of Industrial Microbiology
Representative Publications:
[1] Yumeng Zhou, Lei Shao, Jian Li , Chunbao Zhu, Daijie Chen. An efficient and novel screening model for assessing the bioactivity of extracts against multidrug resistant Pseudomonas aeruginosa using Caenorhabditis elegans Biosci., Biotechnol., Biochem. (in print) 2011
[2] Zhijun Yang, Yu Yin, Yi Chen, Daijie Chen. A Novel Phytotoxic Nonenolide from Phomopsis sp. HCCB03520 Chemistry & Biodiversity (in print) 2011
Hai-Xue Pan, Ji-An Li, Ning-Jun He, Ji-Ye Chen, Yu-Meng Zhou, Lei Shao, Dai-Jie Chen. Improvement of spinosad production by overexpression of gtt and gdh controlled by promoter PermE* in Saccharopolyspora spinosa SIPI-A2090 Biotechnol Lett (2011) 33:733–739
[4] Lei Shao, Jia Huang, Lan Jing, Ji-Ye Chen, Shi-Dong Kan, Min Wang, Ji-An Li, Dai-Jie Chen. Overexpression of aveBIV leading to the improvement of 4'-epidaunorubicin production in Streptomyces coeruleorubidus strain SIPI-A0707 Appl Microbiol Biotechnol (2010) 87:1057–1064
[5] Wen-Rong Hong,Mei Ge,Zhi-Hong Zeng,Li Zhu,Min-Yu Luo,Lei Shao,Daijie Chen. Molecular cloning and sequence analysis of the sisomicin biosynthetic gene cluster from Micromonospora inyoensis. Biotechnol Lett. (2009) 31:449–455
[6] Bin Wu, Licheng Wu, Daijie Chen, Zhijun Yang, Minyu Luo. Purification an characterization of a novel fibrinolytic protease from Fusarium sp. CPCC 480097. J Ind Microbiol Biotechnol.(2009)36:451-459
[7] Bin Wu, Licheng Wu, Lingao Ruan, Mei Ge, Daijie Chen. Screening of Endophytic Fungi with Antithrombotic Activity and Identification of a Bioactive Metabolite from the Endophytic Fungal Strain CPCC 480097. Curr Microbiol. 2009, 58(5):522-527
[8] Shidong Kan, Ji-an Li ,Weiyi Huang, Lei Sha, Daijie Chen, .Microsphere resin chromatography combined with microbial biotranformation for separation and purification of salvianic acid B in aqueous extract of roots of Salvia multiorrihza Bunge. Journal of Chromatography A. (2009) 1216(18):3881-3886
[9] Rijing Liao,Lian Duan, Chun Lei,Haixue Pan, Ying Ding, Qi Zhang, Daijie Chen, Ben Shen, Yi Yu, and Wen Liu Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications. Chemistry & Biology. (2009) 16, 141–14
[10] Zhilong Wang ? Jian-He Xu ? Daijie Chen. Whole cell microbial transformation in cloud point system. J Ind Microbiol Biotechnol (2008) 35:645–656
[11] Dejun Hu, Miao Liu, Xing Xia, Daijie Chen, Fengsheng Zhao, Mei Ge. Preparative Isolation and Purification of Altertoxin I from an Alternaria sp.by HSCCC Chromatographia. (2008) 67(11-12):863-867
[12] Yu Yin, Weiyi Huang, Daijie Chen. Preparation of validoxylamine A by biotransformation of validamycin A using resting cells of a recombinant Escherichia coli. Biotechnol Lett (2007) 29:285–290
[13] Zhilong Wang , Fengsheng Zhao , Daijie Chen , Daotang Li. Biotransformation of phytosterol to produce androsta-diene-dione by resting cells of Mycobacterium in cloud point system. Process Biochemistry. (2006) 41: 557–561
[14] Zhilong Wang, Fengsheng Zhao, Daijie Chen, Daotang Li. Cloud point system as a tool to improve the efficiency of biotransformation. Enzyme and Microbial Technology. (2005) 36: 589–594
[15] Zhilong Wang , Fengsheng Zhao, Xueqin Hao, Daijie Chen, Daotang Li. Model of bioconversion of cholesterol in cloud point system. Biochemical Engineering Journal. (2004) 19: 9–13
[16] Zhilong Wang , Fengsheng Zhao, Xueqin Hao, Daijie Chen, Daotang Li. Microbial transformation of hydrophobic compound in cloud point system. Journal of Molecular Catalysis B: Enzymatic. (2004) 27: 147–153
Book Edition:
[17] Daijie Chen, Baoquan Zhu. Strain Improvement and Fermentation Regulation for Industrial Organisms. Shanghai: Shanghai Scientific and Technological Literature Press, 1995
[18] Daijie Chen. Microbial Pharmaceuticals. Shanghai: East China University of Technology Press, 1999
[19] Daijie Chen. Antibiotics and Bacterial Resistance. Shanghai: East China University of Technology Press, 2001
[20] Daijie Chen. Microbial Pharmaceuticals. Beijing: Chemical Industry Press, 2008
[21] Daijie Chen. Microbial Pharmaceuticals ——A simple tutorial Microbial Pharmaceuticals. Beijing: Chemical Industry Press, 2009
Book Translation:
[22] Daijie Chen. The Principe of Fermentation Technology, Edited by Whitaker, A. Beijing: Pharmaceutical Science and Technology Press of China, 1992
[23] Daijie Chen. Biopolymers of Volume 5, Edited by E. J. Vandamme, A. Steinbuchel. Beijing: Chemical Industry Press 2004
[24] Daijie Chen. Biopolymers of Volume 6, Edited by E. J. Vandamme, A. Steinbuchel. Beijing: Chemical Industry Press 2005
Awards & Honors
1. “Novel Process for Industrial Production of Cyclosporine A” won a first class prize of Shanghai Science and Technology Progress Award in 2004 and a second class prize of National Science and Technology Progress Award in 2005, respectively;
2. “Novel Process for Industrial Production of Vancomycin” won a first class prize of Shanghai Science and Technology Progress Award in 2006 and a second class prize of National Science and Technology Progress Award in 2007 ;
3. “Novel Process for Industrial Production of Miglitol” won a second class prize of Zhejiang Province Science and Technology Progress Award in 2009;
4. The Prize of Eleventh Shanghai Scientific Elite in 2009
contact information
Daijie Chen
School of Pharmacy, Shanghai Jiao Tong University
800 Dong-Chuan Road, Shanghai, 200240
China Office phone: +86-21-3420-7020
Lab. Phone: +86-21-3420-4838
Fax: +86-21-3420-7023
