On-going Researches:
Based on the Self-healing character of diseases, and the fact that after Repair/Regeneration, the tissue mass of the diseased organ does not change, we proposed “the Homeostatic Regulation of Tissue Regeneration”, and further found the research addressing the hypothesis as Regeneromics.
Publications & Patents
(1)Jianjun Hu, Dejun Yan, Jin Gao, Chuanying Xu, Yunsheng Yuan, Runzhi Zhu, Di Xiang, Shunyan Weng, Wei Han, Guoqing Zang and Yan Yu. rhIL-1Ra. Attenuated Hepatotoxicity Primarily by Reducing Hepatocellular Apoptosis in Acetaminophen-Induced Acute Liver Failure Mice. Laboratory Investigation. 2010. (Accepted)
(2)RunZhi Zhu, Di Xiang, Chao Xie, JingJing Li, JianJun Hu, HongLin He, YunSheng Yuan, Jin Gao, Wei Han, Yan Yu. Protective effect of recombinant human interleukin 1 receptor antagonist on carbon tetrachloride-induced acute liver injury in mice. World Journal of Gastroenterology. 2010. (Accepted)
(3)Junfen Jiang, Mei Zhao, Aiying Zhang, Mingfeng Yu, Xiaojuan Lin, Mingyuan Wu, Xiaonong Wang, Huili Lu, Shunying Zhu, Yan Yu, Zhenmin Mao, Wei Han. Characterization of a GSK-3 inhibitor in culture of human cord blood primitive hematopoietic cells. Biomedicine & Pharmacotherapy (2010), doi:10.1016/j.biopha.2010.01.005.
(4)Zhonghui Zhang, Huixian Li, Yiping Qi, Lijuan Du, Shunying Zhu, Mingyuan Wu, Huili Lu, Yan Yu and Wei Han. Recombinant human midkine stimulates proliferation of articular chondrocytes. Cell Prolif. 2010, 43, 184–194.
(5)Hu G, Shen J, Cheng L, Xiang D, Zhang Z, He M, Lu H, Zhu S, Wu M, Yu Y, Wang X, Han W. Purification of a bioactive recombinant human Reg IV expressed in Escherichia coli. Protein Expression and Purification 69 (2010) 186–190.
(6)Xiang D, Zhang J, Chen Y, Guo Y, Schalow A, Zhang Z, Hu X, Yu H, Zhao M, Zhu S, Lu H, Wu M, Yu Y, Moldenhauer A, Han W. Expressions and purification of a mature form of recombinant human Chemerin in Escherichia coli. Protein Expression and Purification 69 (2010) 153–158.
(7)Zhao M, Wu M, Guo L, Jiang J, Huang W, Lin X, Zhang Z, Xiang D, Lu H, Zhu S, Yu Y, Moldenhauer A, Han W. Expression, Purification, and Characterization of a Novel Soluble Form of Human Delta-like-1. Appl Biochem Biotechnol, 2009.3. DOI 10.1007/s12010-009-8603-2,
(8)Zhang ZH, Du LJ, Xiang D, Zhu SY, Wu MY, Lu HL, Yu Y, Han W. Expression and purification of bioactive high-purity human midkine in Escherichia coli. J Zhejiang Univ Sci B. 2009 Feb;10(2):79-86.
(9)Zhang J, Xiang D, Zhu S, Mao W, Lu H, Wu M, Wang Q, Yu Y, Herbst KD, Han W. Interleukin 1 receptor antagonist inhibits normal hematopoiesis and reduces lethality and bone marrow toxicity of 5-fluouracil in mouse. Biomed Pharmacother. 2009 Aug;63(7):501-8.
(10)Yuan Y, Wu X, Ou Q, Gao J, Tennant BC, Han W, Yu Y. Differential expression of the genes involved in amino acids and nitrogen metabolisms during liver regeneration of mice. Hepatol Res. 2009 Mar;39(3):301-12.
(11)Gao J, Li WX, Feng SQ, Yuan YS, Wan DF, Han W, Yu Y. A protein-protein interaction network of transcription factors acting during liver cell proliferation. Genomics. 2008 Apr;91(4):347-55.
(12)Lu H, Yu M, Sun Y, Mao W, Wang Q, Wu M, Han W. Expression and purification of bioactive high-purity mouse monokine induced by IFN-gamma in Escherichia coli. Protein Expr Purif. 2007 Sep;55(1):132-8.
(13)Han W, Yu Y, Liu XY. Local signals in stem cell-based bone marrow regeneration. Cell Res. 2006 Feb;16(2):189-95. Review. Erratum in: Cell Res. 2006 Mar;16(3):328.
contact information
School of Pharmacy, Shanghai Jiao Tong University
800 Dongchuan Road, Shanghai, 200240
Office phone: +86-21-3420-4760
Lab. Phone: +86-21-3420-4902
Fax: +86-21-3420-4760
Regeneromics:
A field of biotechnology concerned with discovery of functional genome of regeneration and developing drugs thereafter aimed at protective prevention and/or accelerating native repair/regeneration capability of damaged, diseased, or metabolically deficient organs, tissues, and cells via biologics, small molecules, and natural products.
To deliver the power of Regeneromics, we have developed a proprietory technology “Prometheus Technology”, which are applied to the subprograms of bone marrow, intestinal epithelial, liver, pancreas, heart, thymus, and cartilage, aimed at unmet medical conditions associated with the organs.
