ShiKai Yan Ph.D., Associate Prof.
• Yan Zhu Assistant
Research Field
Bioactive components from traditional Chinese medicine (TCM) and compound traditional Chinese medicine;
Chemical Biology;
Metabolism in vivo;
Quality control of TCM;
Publications & Patents
• Guo-Wei Wang, Jiang-Jiang Qin, Xiang-Rong Cheng, Yun-Heng Shen, Lei Shan, Huizi Jin & Wei-Dong Zhang. Inula sesquiterpenoids: structural diversity, cytotoxicity and anti-tumor activity. Expert Opin. Investig. Drugs 23(3): 317-345 (2014)
• Jie Ren, Yuanyuan Zhang, Huizi Jin, Jing Yu, Yueyang Zhou, Fang Wu, and Weidong Zhang. Novel Inhibitors of Human DOPA Decarboxylase Extracted from Euonymus glabra Roxb. ACS Chem. Biol. 9, 897−903 (2014).
• Chao Li, Longyang Dian, Weidong Zhang, Xiaoguang Lei. Biomimetic Syntheses of (−)-Gochnatiolides A–C and (−)-Ainsliadimer B. J. Am. Chem. Soc., 2012, 134 (30): 12414–12417.
• Bin Guan, Tao Li, Xi-Ke Xu, Xu-Feng Zhang, Pan-Lei Wei, Cheng-Cheng Peng, Jian-Jun Fu, Qi Zeng a, Xiang-Rong Cheng, Shou-De Zhang, Shi-Kai Yan, Hui-Zi Jin, Wei-Dong Zhang. g-Hydroxynitrile glucosides from the seeds of Prinsepia utilis. Phytochemistry 105: 135–140 (2014).
• Shuang Liang, Shan-Xiang Liu, Hui-Zi Jin, Lei Shan, Shi-Chong Yu, Yun-Heng Shen, Hui-Liang Li, Qiu-Ye Wu, Qing-Yan Sun and Wei-Dong Zhang. Two novel innovanoside dimers from Daphne aurantiaca and a concise total synthesis of diinnovanoside A. Chem. Commun., 49, 6968—6970 (2013).
• Hu Yuan, Kai-Jian Bi, Bo Li, Rong-Cai Yue, Ji Ye, Yun-Heng Shen, Lei Shan, Hui-Zi Jin, Qing-Yan Sun, and Wei-Dong Zhang. Construction of 2‑Substituted-3-Functionalized Benzofurans via Intramolecular Heck Coupling: Application to Enantioselective Total Synthesis of Daphnodorin B. Org. Lett., 15(18): 4742-4745 (2013).
• Jiang-Jiang Qin, Hui-Zi Jin, Ying Huang, Shou-De Zhang, Lei Shan, Sukesh Voruganti, Subhasree Nag, Wei Wang, Wei-Dong Zhang, Ruiwen Zhang. Selective cytotoxicity, inhibition of cell cycle progression, and induction of apoptosis in human breast cancer cells by sesquiterpenoids from Inula lineariifolia Turcz. European Journal of Medicinal Chemistry 68: 473-481 (2013).
• Xiang-Rong Cheng, Shou-De Zhang, Chun-Hui Wang, Jie Ren, Jiang-Jiang Qin, Xue Tang, Yun-Heng Shen, Shi-Kai Yan, Hui-Zi Jin, Wei-Dong Zhang. Bioactive eudesmane and germacrane derivatives from Inula wissmanniana Hand.-Mazz. Phytochemistry 96: 214–222 (2013).
• Bin Guan, Cheng-Cheng Peng, Qi Zeng, Xiang-Rong Cheng, Shi-Kai Yan, Hui-Zi Jin, Wei-Dong Zhang. Cytotoxic Pentacyclic Triterpenoids from Prinsepia utilis. Planta Med 79: 365–368 (2013).
• Jiang-Jiang Qin, Ying Huang, Dan Wang, Xiang-Rong Cheng, Qi Zeng, Shou-De Zhang, Zhen-Lin Hu, Hui-Zi Jin and Wei-Dong Zhang*. Lineariifolianoids A–D, rare unsymmetrical sesquiterpenoid dimers comprised of xanthane and guaiane framework units from Inula lineariifolia. RSC Adv., 2: 1307-1309 (2012).
Awards & Honors
• National Outstanding Young Scientist Foundation of China (2007)
• National Prize for Progres in Science and Technology (2010)
• Prize for Progres in Science and Technology Shanghai (2012)
